{"id":"ifip_49612","title":"Do human-infecting Yersinia enterocolitica Isolates exhibit adaptive phenotypes?","year":2026,"publisher":"IFIP","excerpt":"Yersinia enterocolitica strains of biotype 4 (BT4) are the most prevalent in human cases in France, followed by biotype 2 (BT2). We evaluated four BT4 porcine (P) isolates and four BT2 bovine (B) isolates for their ability to survive at 4 °C in culture broth and on meat, exhibit motility at 4 °C and…","url":"https://rd-agri.fr/detail/DOCUMENT/ifip_49612","links":{"self":"/rd-agri/documents/ifip_49612"},"description":"Yersinia enterocolitica strains of biotype 4 (BT4) are the most prevalent in human cases in France, followed by biotype 2 (BT2). We evaluated four BT4 porcine (P) isolates and four BT2 bovine (B) isolates for their ability to survive at 4 °C in culture broth and on meat, exhibit motility at 4 °C and 12 °C, adhere to stainless steel at 12 °C, resist five biocides, and infect human intestinal Caco-2 cells. The objective was to determine whether animal isolates that genetically cluster with human (H) isolates (P+H+, B+H+) differ phenotypically from non-clustering isolates (P+H−, B+H−), based on core genome multi-locus sequence typing (cgMLST) using allelic distance thresholds of ≤5 for BT4 and ≤3 for BT2 isolates. No significant difference was observed for BT4 between P+H+ and P+H− isolates, nor for BT2 between B+H+ and B+H− isolates, for any test, except for motility. Porcine isolates clustering with human isolates (H+) exhibited a significantly reduced motility compared with non-clustering isolates (H−) (p-value < 0.05). In contrast, bovine isolates clustering with human isolates (H+) showed a significantly higher motility than non-clustering isolates (H−). Motility plays a role in the early stages of biofilm formation but is not directly involved in virulence, as Y. enterocolitica becomes non-motile at 37 °C. Animal isolates that did not cluster with human isolates displayed traits enabling their transmission along the food chain, suggesting potential low-level human exposure, asymptomatic carriage, or links to unreported infections.\n\n\nArticle en accès ouvert disponible ici (s’ouvre dans le site de l’éditeur)","language":"eng","keywords":[],"project":{"code":"26PIT090","name":"Programme annuel IFIP 2026"},"notice-url":"https://ifip.asso.fr/documentation/49612-Do-human-infecting-Yersinia-enterocolitica-Isolates-exhibit-adaptive-phenotypes?","document-url":"https://docs.ifip.asso.fr/default/digitalCollection/DigitalCollectionAttachmentDownloadHandler.ashx?parentDocumentId=49612&documentId=49613&skipWatermark=true&skipCopyright=true","productions":[],"taxa":[],"production-systems":[],"areas":[],"pests":[]}